Identification of Genes in the Dorsal Raphe Nucleus Regulated by Chronic Stress and Citalopram

I hereby declare that this submission is my own work and that, to the best of my knowledge and belief, it contains no materials previously published or written by another person nor material which to a substantial extent has been accepted for the award of any other degree of the university or other institute of higher education, except where due acknowledgment has been made in the text. Signature Name Date and place ……………………… ……………………….. ………………………….. 2 I have to say 'thank-you' to my family and all my friends, wherever they are. Much of appreciation goes to Mom and Dad, and then the rest of my family; their support and belief in me have always inspired me in my endeavours. Last, but certainly not least, I thank my wife, my first and only love Xiao Yang, whose love gave me the strength and encouragement to follow the path that I felt was right, and whose patience and unselfishness allowed me the freedom to complete the task. This dissertation is lovingly dedicated to all those people. Harry Harlow's (1905-1981) opinion regarding the use of animal models in the study of psychiatric disorders: " You have to be crazy to use animal models for the study of human psychopathology " , and then he added: " you have to be crazy if you do not because of all the knowledge that is gained from work with animals ".